How's the 16u2 connected to the 2560?

i would like to make a board similar to the arduino mega but i just need the 16u2 the 2560 and some tblokcs besides the basic components like the 16mhz crystal and a sd card reader, however i'm not sure about how is the 16u2 connected to the 2560

The full schematic of the Arduino Mega2560 is posted on line. Everything is open source.

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