I got an error during compilation of Blink sketch on Uno

Arduino: 1.6.13 (Windows 10), Board: "Arduino/Genuino Uno"

cc1plus.exe: fatal error: opening output file preproc\ctags_target_for_gcc_minus_e.cpp: Permission denied

compilation terminated.

exit status 1
Error compiling for board Arduino/Genuino Uno.

This report would have more information with
"Show verbose output during compilation"
option enabled in File -> Preferences.

What to do???

That's a file permissions error on the output directory - that's Windows specific arcana. It could
be caused by various things.

what to do now??

Back to basics.

Is this YOUR own personal computer ? (not a company or loaned computer)
Are you the ONLY user ?
Are you on a company or educational network or any other form of network ?
Do you have Administrator priviledges ? (real ones not just pseudo user admin)
What security do you use AV etc etc ? ( list them all ! )
Have you tried to use just an unzipped version of the IDE ?

yeah pretty right