Thanks for answering 
Indeed I have tried a very reduced and controlled code of that library. Attached link of the library GitHub - switchdoclabs/SDL_Arduino_INA3221: Corrected SDL_Arduino_INA3221.
I have tried, with other I2C modules and it happens exactly the same with ItsyBitsy RP2040. But with Raspberry PICO, which has the same RP2040 microcontroller it works wonderfully. So I rule out the incompatibility of the library with the RP2040 kernel.