ILI9481 16bit paralell 3.5"TFT touch display + Arduino "UNO+Wifi" or Wemos R3

Remove your shoes. Do the maths.

A 16-bit TFT needs 16 data lines with 4 or 5 control lines.
How many pins do you have on your Uno?
Wemos R3 sounds like ESP8266. How many pins on an ESP8266?

Post a link to your actual ILI9481 display. e.g. the Ebay purchase.

David.