If one end of the wire reads 4.99V constant and the other reads 4.57 , 4.56V, then your wire has problems because your wire should have damn close to 0R resistance and so near as possible 0 difference in potential.
Can you post an image(s) of your basic setup now please with just the components in your diagram shown?
Hi,
So if V1 and V2 are 40mV and 60mV volt drops = 100mV, how can the difference in potential between the wires at the ESP32 be;
4.99V - 4.56V = 0.43V or 430mV ????
Where are you measuring the 4.56V, at what terminations?
I agree, pull everything out of the protoboards, turn them through 180degrees and fit your components back onto the board.
That is, place your components in a totally different part of each board.
Also check the solder joints of all your PCB modules.
I have done a direct connection right to the board, and that has seemed to have worked. Just having problems with the amplifier but that should be a easier fix.