MEGA 1280 with FTDI

Is there any issue using the MEGA 1280 IC with an FTDI chip? Obviously 8U2 is being used on their reference board but can I just go down the FTDI route as with previous ICs?

The original Atmega used the FTDI chip.

Check the schematic link on this page:

Thanks. My board design is taking shape. The alternative method seem soooooo much more complicated !