Mega 2560 not working

Dear all, i have mega2560, there is no output from any digital pin, and no changing in analog values, while using proper program. I think boot loader is working fine , because every time i press reset button there is blink in LED attached with pin13. RX ,TX blinking when uploading the program. 5v and 3.3v supply is good ,when checked with multi meter. But digital and anlog pin is not working. any idea what to check to find out the solution of this problem.

Thank you Suyash