Do you have anything connected to the Mega (e.g., shields, wiring, modules, a 3D printer)? If so, try disconnecting everything from the board and then uploading to just the board by itself.
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Do you have anything connected to the Mega (e.g., shields, wiring, modules, a 3D printer)? If so, try disconnecting everything from the board and then uploading to just the board by itself.