Multiple cards on one RC522

Yes, several

If you don't want to introduce more hardware such as a keyboard/keypad or screen then one card could be dedicated as a "master" and reading that could trigger other functionality such as adding or deleting authorised cards.

This would also require the use of some storage medium, such as the EEPROM to store the current list of authorised cards so that it would not be affected by a power cut or reset.

As I said, how complicated do you want things to get ?