My mini Pro can't be program

Hi, so recently I bought a Mini Pro. It's ome packed with an USB to TTL adapter. So when I'm trying to program it for the first and second time, it doesn't work. Later, I tried again, suprisingly, it worked. But now when I'm trying to program it again, it doesn't work. It's always say avrdude stk500_getsync() not in sync resp=0x00 . I already tested my USB to TTL adapter, and it work perfect. Is that a problem with my Mini Pro?