Could you like or comment if you are interesed in connecting openthread.io the open source version of Google Home Nest software to the Nano 33 BLE. I have got several Nordic nRF52840 types of hardware working with Openthread. The Nano 33 BLE is based on the nRF52840 so it might work.
I would like to make an Arduino basic openthread library of their github site, but I am new to Arduino libraries, any suggestions or examples of libraries with sub-folders in the src folder would be helpful.
The other option is to see if https://openthread.io generated .hex files can be directly loaded onto the nano 33 BLE.