not in sync: resp=0x53

Has anyone seen this problem and fixed successfully.
PLEASE HELP and share your effective solution

Arduino: 1.8.9 (Windows 7), Board: "Arduino/Genuino Uno"

Sketch uses 2880 bytes (8%) of program storage space. Maximum is 32256 bytes.
Global variables use 190 bytes (9%) of dynamic memory, leaving 1858 bytes for local variables. Maximum is 2048 bytes.
C:\Program Files\Arduino\hardware\tools\avr/bin/avrdude -CC:\Program Files\Arduino\hardware\tools\avr/etc/avrdude.conf -v -patmega328p -carduino -PCOM4 -b115200 -D -Uflash:w:C:\Users\ADMINI~1\AppData\Local\Temp\arduino_build_915891/robot_do_line.ino.hex:i

avrdude: Version 6.3-20171130
Copyright (c) 2000-2005 Brian Dean, http://www.bdmicro.com/
Copyright (c) 2007-2014 Joerg Wunsch

System wide configuration file is "C:\Program Files\Arduino\hardware\tools\avr/etc/avrdude.conf"

Using Port : COM4
Using Programmer : arduino
Overriding Baud Rate : 115200
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 1 of 10: not in sync: resp=0x53
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 2 of 10: not in sync: resp=0x53
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 3 of 10: not in sync: resp=0x53
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 4 of 10: not in sync: resp=0x53
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 5 of 10: not in sync: resp=0x53
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 6 of 10: not in sync: resp=0x53
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 7 of 10: not in sync: resp=0x53
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 8 of 10: not in sync: resp=0x53
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 9 of 10: not in sync: resp=0x53
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 10 of 10: not in sync: resp=0x53

avrdude done. Thank you.

Problem uploading to board. See Arduino Help Center for suggestions.

This report would have more information with
"Show verbose output during compilation"
option enabled in File -> Preferences.

Remove any connections to pins 0 and 1. These pins are used for communication with your computer, including uploads. Connecting anything to these pins can interfere with uploads.

Make sure you have the correct board selected from the Tools > Board menu.

Make sure you have selected the port of your Arduino board from the Tools > Port menu.

Sometimes the port will be labeled with the board name in the menu. Other times it will not. If you don’t know which port is your Arduino, you can find it like this:

  • Unplug your Arduino board from the computer.
  • Tools > Port
  • Note the ports, if any, listed in the menu.
  • Close the Tools menu
  • Plug your Arduino board into the computer.
  • Tools > Port - The new port listed in the menu is your Arduino board.