Not typical "avrdude: stk500_getsync(): not in sync: resp=0x00"

My latest sketch was working with 2 devices on l2c, one LCD displaying digital sensors parameters and time from second device connected to l2c, Real Time Clock. And then this happened.

Info I'm getting from newest beta arduino GUI on MacOS:

avrdude: Version 5.11, compiled on Sep 2 2011 at 18:52:52
Copyright (c) 2000-2005 Brian Dean, http://www.bdmicro.com/
Copyright (c) 2007-2009 Joerg Wunsch

System wide configuration file is "/Users/mad/Downloads/Arduino.app/Contents/Resources/Java/hardware/tools/avr/etc/avrdude.conf"
User configuration file is "/Users/mad/.avrduderc"
User configuration file does not exist or is not a regular file, skipping

Using Port : /dev/tty.usbmodem621
Using Programmer : arduino
Overriding Baud Rate : 115200
avrdude: Send: 0 [30] [20]
avrdude: Send: 0 [30] [20]
avrdude: Send: 0 [30] [20]
avrdude: ser_recv(): programmer is not responding
avrdude: stk500_recv(): programmer is not responding

avrdude done. Thank you.

processing.app.debug.RunnerException
at cc.arduino.packages.uploaders.SerialUploader.uploadUsingPreferences(SerialUploader.java:125)
at processing.app.Sketch.upload(Sketch.java:1719)
at processing.app.Sketch.exportApplet(Sketch.java:1625)
at processing.app.Sketch.exportApplet(Sketch.java:1597)
at processing.app.Editor$DefaultExportHandler.run(Editor.java:2397)
at java.lang.Thread.run(Thread.java:695)
Caused by: processing.app.debug.RunnerException: Problem z wgrywaniem na p?yte. Sprawd? http://www.arduino.cc/en/Guide/Troubleshooting#upload w poszukiwaniu sugestii.
at cc.arduino.packages.Uploader.executeUploadCommand(Uploader.java:111)
at cc.arduino.packages.uploaders.SerialUploader.uploadUsingPreferences(SerialUploader.java:123)
... 5 more

Now I'm fooling around with the reset button as You suggested, no luck so far but I will try anyway