Pololu AVR programer for MEGA 2560

Hi,

Has anybody use the Pololu AVR programmer to download the program into the Mega 2560?

I have hook up the programmer to my Mega and has selected my programmer from Tools>Programmer>pololu

When I try to upload using programmer, I get this error "avrdude stk500v2_command() command failed "

There are 2 virtual com port and I have tried both.

Sometimes I get this error "avrdude: usbdev_open(): did not find any USB device "usb""

If anyone knows the step to proceed, please help