problem on uploading to Mega 2560.

Development Tools IDE 1.x
1

I Have some problem when uploading to Mega2560, how can i solve this .?

avrdude: ser_open(): can't open device "\.\COM4": The system cannot find the file specified.

avrdude: ser_drain(): read error: The handle is invalid.

Problem uploading to board. See http://www.arduino.cc/en/Guide/Troubleshooting#upload for suggestions.

2

I am having the same problem. I had IDE 1.6.5 installed and it gave me this result so I uninstalled 1.6.5 and installed 1.0.6 and got the following message

  This report would have more information with
  "Show verbose output during compilation"
  enabled in File > Preferences.
Arduino: 1.0.6 (Windows 7), Board: "Arduino Mega 2560 or Mega ADK"
Binary sketch size: 11,438 bytes (of a 258,048 byte maximum)

processing.app.SerialNotFoundException: Serial port 'COM1' not found. Did you select the right one from the Tools > Serial Port menu?

	at processing.app.Serial.<init>(Serial.java:191)

	at processing.app.Serial.<init>(Serial.java:77)

	at processing.app.debug.Uploader.flushSerialBuffer(Uploader.java:77)

	at processing.app.debug.AvrdudeUploader.uploadViaBootloader(AvrdudeUploader.java:175)

	at processing.app.debug.AvrdudeUploader.uploadUsingPreferences(AvrdudeUploader.java:67)

	at processing.app.Sketch.upload(Sketch.java:1666)

	at processing.app.Sketch.exportApplet(Sketch.java:1622)

	at processing.app.Sketch.exportApplet(Sketch.java:1594)

	at processing.app.Editor$DefaultExportHandler.run(Editor.java:2382)

	at java.lang.Thread.run(Thread.java:619)

My "Serial Port" option in the Tools menu is grayed out, and when trying to install the drivers via Device Manager, my (Windows 7 x64) will only allow me to navigate to the Drivers folder, and not the arduino.inf file. Sorry to jack this thread, but I didn't want to start a new thread for the same/similar issue. Please help us.

TYIA