Problem? using Arduino Uno R4 Minima and I2C

Projects Networking, Protocols, and Devices
12

No it is not. and no you don't.

I have used a 3V3 bus on an R4, just connect the pull up resistors to 3V3. I was driving an MPR121 touch sensor board. Note this is not the Adafruit board that contains level shifters, but a raw MPR121 board.