Problem with arduino as ISP and avrdudess

Hello everyone! I hope someone could help me with this or at least give me some ideas...
I designed my own board with an atmega32u4 and I programmed with an arduino uno as isp... at the begginig I had many problems to make it work. Avrdudess can't recognize the atmega32u4... but finally I solved when I change all the wires for new ones... then I could programed and I did many times... the thing is I have the problem again, and I change all the wires again but the problem persist, everything looks fine but avrdudess can't recognize the microcontroller, but sometimes it does... is very weird... Someone have any idea about what coul de happening?? Is the arduino as isp a reliable device to program another microcontroller?
Thanks

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