problem with stk 500

Arduino: 1.8.9 (Windows Store 1.8.21.0) (Windows 10), Board: "Arduino/Genuino Uno"

Sketch uses 2078 bytes (6%) of program storage space. Maximum is 32256 bytes.
Global variables use 189 bytes (9%) of dynamic memory, leaving 1859 bytes for local variables. Maximum is 2048 bytes.
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 1 of 10: not in sync: resp=0x4f
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 2 of 10: not in sync: resp=0x4f
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 3 of 10: not in sync: resp=0x4f
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 4 of 10: not in sync: resp=0x4f
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 5 of 10: not in sync: resp=0x4f
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 6 of 10: not in sync: resp=0x4f
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 7 of 10: not in sync: resp=0x4f
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 8 of 10: not in sync: resp=0x4f
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 9 of 10: not in sync: resp=0x4f
avrdude: stk500_recv(): programmer is not responding
Problem uploading to board. See http://www.arduino.cc/en/Guide/Troubleshooting#upload for suggestions.
avrdude: stk500_getsync() attempt 10 of 10: not in sync: resp=0x4f

This report would have more information with
"Show verbose output during compilation"
option enabled in File -> Preferences.

again the same thing i have got after unpluging of TX and RX pins

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