"programmer is not responding" repeated error

My arduino uno had stopped working. No codes can be uploaded, same error repeatedly comes that is "programmer is not responding, 10 attempts (avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 10 of 10: not in sync: resp=0x03)". There is ATmega328P - PU ic in arduino uno. Iam also trying to run bootloader (master - slave) using last signature as 0x0F. But the same error repeats even at the run of bootloader. What to do?
Please Help !! Completely in distress.