Programming with FT232RL

is it possible to upload my sketches on MKR boards with a FT232RL USB to serial adapter like on bare ATMEGA328P chips?
I plan to fit my project in a very small box and if i need to upload updates i have to unscrew the whole thing. Instead i can mount a pin header and upload it there.
The problem i see is that the all in one chip solution with the SAMD21 maybe doesent allow those procedere because the USB N and the USB P are direct connected to the microcontroller.