Questions regarding MIDI controller project

I'm thinking in building 64 pot controller. I never used arduino before, but I can code and my father can help with electronics and soldering.

Is there any downsides with using multiplexers? I need that pots would be responsive and with good resolution.

As I undersnad only pro micro can send MIDI directly over USB?

Is there any problems when using multiple UNO's with the same compter? I'm thinking maybe spliting in two separate boxes with 32 pots each.

with proper amount of proper multiplexer it can be even 1 Micro Pro. but my favorite in such case is STM32 Blue Pill.

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I haven't heard about STM32F103C8T6. What are its advantages? Any useful info on it? I suspect its behaves different than orginal arduino boards?

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