Real-time control with the PC interface

It's difficult to offer advice without knowing what capabilities you do have.

IMO the absolute simplest is a wired serial connection with the data sent using the Serial Monitor in the Arduino IDE. It will work but is very crude. You might key commands like "s20","s50" for speeds and perhaps "m1","m2" for modes of operation.

Whatever you choose will need some code in the Arduino and some careful design of the main program.

Steve