I have a Core i7/EVGA x58 motherboard/12 gigs of DDR3 1600/GeForce GTX 285/700 Watt PSU. I'll probably upgrade the GPU when the 485 comes out, which will only increase the power consumption further. My research involves computations on huge matrices (up to 100,000 x 100,000) on the GPU, so graphics power is important.