We've been using an Arduino Due for our project, we need it because of the ability to have so many interrupts (we need ~20). We've tried using a Zero, which works decent, but only has ~11 interrupts ( Zero claims it has more, but when I set up a test system I remember there was only ~11 that were actually unique, multiple pins trigger the same interrupt)
What other hobbiest microcontroller has lots of interrupts?
Yes, we could redesign the system to multiplex the signals and combine them into one interrupt channel, we've gone down that route a bit in the past and it was too complex. We're trying to measure laser pulses, so it has to be ridiculously fast so from our experiments it was easiest to just have individual interrupts. Also, if we redesign now, we need all new hardware and circuit boards, so thats a last ditch effort.