Running 40-60 RGB LED's

If you have discrete LEDs, use common anode and then use shift register to sink current thru the cathodes. Do you need more than white, red, green, blue, red+green, red+blue, green+blue, off?
If not, then a shift register board like this one with 96 cathode-drive outputs can drive 32 LEDs, and can be daisy chained for 64 LEDs.

If you need PWM for each color for more color choices (like 1/2 red, 1/4 green, 1/3 blue) then you need a chip like WS2803, can drive 6 LEDs each with 256 levels, or TLC5490, 5 LEDs with 4K levels.
Or you may want to look at LED strings with individually controllable RGB LEDs controlled in different ways from an Arduino serial data stream.