Running PC programs with Arduino

Is it possible to use the Arduino to trigger PC programs. For example, I would like to use sensors on the Arduino to trigger video playback programs that play on the PC and a connected monitor. Can this be done via the USB port? Thanks.

Is it possible to use the Arduino to trigger PC programs.

The Arduino can send serial data. If there is an application listening to the serial port, that application can then launch/communicate with PC programs. GoBetwino is one such application.