Scripts not uploading

Every time I try to upload a script I get the message back - avrdude: stk500_getsync() : not in sync: resp= 0x00

What does this signify? I have tried all four usb ports on the PC and get the same error message. Is there any way I can ping the Acquino to see if is receiving anything from the PC. I have checked in Device Manager and USB port 4 has been desigated as a a USB Serial Port (FTDI) and it is working properly. I am new to this and am floundering.