Sketch uploading problem in Uno

I get following error while uploading my sketch in Uno . Pl note even after disabling my QH Anti Virus still same error is shown.

Arduino: 1.8.7 (Windows 10), Board: "Arduino/Genuino Uno"

Build options changed, rebuilding all
Assembler messages:

Fatal error: can't create core\HardwareSerial2.cpp.o: Permission denied

exit status 1
Error compiling for board Arduino/Genuino Uno.