If there is impossible to bootloader my self-design mega2560PCB by arduino mega2560 without 10uf capacity connecting reset and 5V
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According to https://docs.arduino.cc/built-in-examples/arduino-isp/ArduinoISP/#how-to-wire-your-boards, you need the capacitor on the programmer board to be able to program the target board.
You should provide more detailed information, like schematics and log.
Capacitor for bootloading process is needed to prevent resetting the programmer Arduino board. It depends on the used avrdude protocol if the reset pulse is provided or not.
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