STK500 over radio question

Hello everyone, I want to make/buy two radio Serial extenders (such as nRF24, XBee etc) and plug these between a computer with USB2Serial and ArduinoISP programmer. Does ArduinoISP working only via Serial lines (Tx, Rx) or it's also need DTR?

Now I have Duemilanove board which I use as ArduinoISP. I'd like to make it radio-capable for wireless programming via this setup:

PC->USB->FTDI IC->Serial-RF24 (first MCU)->wireless->RF24-Serial (second MCU)->ArduinoISP (third MCU)->target (4th MCU). Will it work?