stk500_recv(): programmer is not responding

Hi There
I've struggled with the same issue:
vrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 1 of 10: not in sync: resp=0x8f
...
avrdude: stk500_getsync() attempt 10 of 10: not in sync: resp=0x8f
Problem uploading to board. See http://www.arduino.cc/en/Guide/Troubleshooting#upload for suggestions.

I might have an interesting observation, which someone might be able to verify!?

When I use an older Arduino version (1.6.13), I do not experience any issue. E.g. the Blink sketch uploads without any issue, and executes on the Nano.

I see the issue of 'programmer is not responding...' in versions 1.8.9 (Windows Store 1.8.21.0) and on the Arduino WEB.