If I were doing an industrial application, I'd look at the Gator board from http://www.ruggedcircuits.com/. It has some input pin protection.
As to replacing the board in the future, these boards are inexpensive enough (by industrial use standards) that you could buy spares and keep them on the shelf. If you use up your spares, and the board you were using has been discontinued, chances are that someone will have produced something that is cheaper, faster, and better, and it may even be backwards-compatible.
-Mike