I just tried, still not responding! I am running out of ideas... maybe the FT232RL eeprom needs to be programmed differently to work with the optiboot?
I have quite a few FT232RLs (Not the Breakout though) and the only thing to change is the board to Uno. The breadboard Arduino project uses a FTDI Breakout and the only connections are Vcc/Gnd/Rx/Tx which is all that I use.