Upload Error Arduino UNO.

Upload error to the plate Arduino UNO takes a high time to build, followed by the following error.
Arduino: 1.6.9 (Windows 10) Sign: "Arduino / Genuino Uno"

The sketch uses 1066 bytes (3%) storage space for programs. The maximum is 32,256 bytes.
Global variables using 9 bytes (0%) dynamic memory, leaving 2039 bytes for local variables. The maximum is 2,048 bytes.
avrdude: stk500_recv (): programmer is not responding
avrdude: stk500_getsync () attempt 1 of 10: not in sync: resp = 0xe8
avrdude: stk500_recv (): programmer is not responding
avrdude: stk500_getsync () attempt 2 of 10: not in sync: resp = 0xe8
avrdude: stk500_recv (): programmer is not responding
avrdude: stk500_getsync () attempt 3 of 10: not in sync: resp = 0xe8
avrdude: stk500_recv (): programmer is not responding
avrdude: stk500_getsync () attempt 4 of 10: not in sync: resp = 0xe8
avrdude: stk500_recv (): programmer is not responding
avrdude: stk500_getsync () attempt 5 of 10: not in sync: resp = 0xe8
avrdude: stk500_recv (): programmer is not responding
avrdude: stk500_getsync () attempt 6 of 10: not in sync: resp = 0xe8
avrdude: stk500_recv (): programmer is not responding
avrdude: stk500_getsync () attempt 7 of 10: not in sync: resp = 0xe8
avrdude: stk500_recv (): programmer is not responding
avrdude: stk500_getsync () attempt 8 of 10: not in sync: resp = 0xe8
avrdude: stk500_recv (): programmer is not responding
avrdude: stk500_getsync () attempt 9 of 10: not in sync: resp = 0xe8
avrdude: stk500_recv (): programmer is not responding
avrdude: stk500_getsync () attempt 10 10: not in sync: resp = 0xe8
Problem loading to the plate. See http://www.arduino.cc/en/Guide/Troubleshooting#upload for suggestions.

What does Windows Device Manager show?