upload issues

avrdude: stk500_recv(): programmer is not responding

mac 10.7, arduino Duemilanove 328, /dev/tty.Bluetooth.PDA.Sync

used to work on my older mac, am trying to upload an analog firmata but even when i try 'blink' I get this message
have tried several usb cables, have been pressing reset, have got reset flashes then stops and remains so. nothing conductive anywhere near the board and the chips feel solid

sorry if this has an obvious solution