With 100F caps on the crystal, that part will never oscillate.
Use 22pF instead.
1mOhm (milliOhm) will also effectively short the 2 pins together. Use 1 MOhm (Mega-ohm) instead, or none at all. I do not use one in my designs.
100 ohm pullup on Reset is likely too strong for a programmer to be able to pull the pin low. 10K is all that is needed.
Add a 2nd 0.1uF cap for AVCC - VCC and AVCC should each have a cap.
Same for the HC4067s - 0.1uF cap from their VCC pin to Gnd.
The 0.1uF should be right next to the VCC pin(s) for all devices.
Aref should also have a 0.1uF cap from the pin to Gnd.
10K on LED1 will make for a very, very dim LED. Even 5.1K is very dim. Use 1K, 2.2K.
You don't need the resistor on the 4067 pin 15.
So except for that, it looks good.