uploading error.

This is the mentioned error: Arduino: 1.8.3 (Windows 10), Board: "Arduino/Genuino Uno"

Sketch uses 1888 bytes (5%) of program storage space. Maximum is 32256 bytes.
Global variables use 188 bytes (9%) of dynamic memory, leaving 1860 bytes for local variables. Maximum is 2048 bytes.
avrdude: ser_open(): can't open device "\.\COM5": The system cannot find the file specified.

Problem uploading to board. See http://www.arduino.cc/en/Guide/Troubleshooting#upload for suggestions.

This report would have more information with
"Show verbose output during compilation"
option enabled in File -> Preferences.

The thing is the board works for some times and after a while it showing the above error.when it displaying this error ,the power LED of my board is not blinking.
please help me.