USB-serial ligfht connect to FIO

Hallo, I have a FIO 1.6 with 3.3 on the serial can I program this by using the arduini FTDI light 5 v? To me it looks rather confiusing 5 v from USB and 3.3 v for program the FIO. I like to double check first gefore I blow the FIO.

help appriciated. ilioSS