recently started using a windows 11 s device and had no problem running arduino uno for a couple weeks. let it sit for a week and came back to it and unable to even verify a sketch without this error.. (i can still use the serial monitor and see its running the last sketch)
Arduino: 1.8.19 (Windows Store 1.8.57.0) (Windows 10), Board: "Arduino Uno"
fork/exec C:\Users\david\Documents\ArduinoData\packages\arduino\tools\avr-gcc\7.3.0-atmel3.6.1-arduino7/bin/avr-g++.exe: Your organization used Device Guard to block this app. Contact your support person for more info.
You very likely need to disable device guard. It probably got triggered by a 3rd party app reacting to an update.
There is no published method for windows 11, but a guide for 10 ought to do the trick.
Then check defender and AV settings.