Using multiple interrupts

Hi, I'm trying to build a heater damper controller with 3 zones. I'm new to Arduino so please forgive me if my code is hard to follow. I intend to use a Arduino MEGA with all 6 interrupts, 3 to increase the set-points and 3 to decrease them. I am currently working with a UNO and have only written two of the interrupts. The interrupt on pin 2 works ok, but will need some debouncing. But i cant get the one on pin 3 to work, please let me know if anyone can see where i went wrong. Thanks.

#include <LiquidCrystal.h>                                   

int Damper1 = 8;
int Damper2 = 9;
int Damper3 = 10;
int Fan = 0;

volatile int SetPoint1 = 45;
volatile int SetPoint2 = 45;
volatile int SetPoint3 = 45;

float voltage = 4.88;                                                               

float tempC1 = 0;                                               
float tempC2 = 0;
float tempC3 = 0;

float tempAC1 = 0;
float tempAC2 = 0;
float tempAC3 = 0;

int tempPin1 = 0;                                               
int tempPin2 = 1; 
int tempPin3 = 2; 

float samples1[10];                                            
float samples2[10];
float samples3[10];

int i1;
int i2;
int i3;

//volatile int changeButton = 2;
volatile int upButton1 = 2;
volatile int downButton1 = 3;

LiquidCrystal lcd(12, 11, 7, 6, 5, 4);

const int backlight = 13;
int changeButtonState = 0;
int upButton1State = 0;
int downButton1State = 0;


void setup(){
 
  pinMode(upButton1,INPUT_PULLUP);
  pinMode(downButton1,INPUT_PULLUP);

  pinMode(backlight, OUTPUT);
  digitalWrite(backlight, LOW);

  digitalWrite(Damper1, HIGH);
  digitalWrite(Damper2, HIGH);
  digitalWrite(Damper3, HIGH);

  attachInterrupt(digitalPinToInterrupt(upButton1),upSetPoint1,CHANGE);
  attachInterrupt(digitalPinToInterrupt(downButton1),downSetPoint1,CHANGE);
  
  Serial.begin(9600);

  lcd.begin(16, 2); 
  
  pinMode(Damper1, OUTPUT);
  pinMode(Damper2, OUTPUT);
  pinMode(Damper3, OUTPUT);
}

void loop(){
  
  {  
  //Room 1
  Serial.println(""); 
  Serial.println("Room 1 Raw data: ");
 
  for(i1 = 0;i1<=9;i1++){                                           
  samples1[i1] = ( voltage * analogRead(tempPin1) * 100.0) / 1024.0;
  
  Serial.println(samples1[i1]);                                           
  
  tempC1 = tempC1 + samples1[i1];                                   
  delay(800);
  }  
  
  tempAC1 = tempC1/10.0;

  Serial.print(" Room 1 average  " ); 
  Serial.println(tempAC1);       

  lcd.setCursor(0, 0);
  lcd.print("Setpoint 1: ");
  lcd.print(SetPoint1);
  lcd.setCursor(0, 1);
  lcd.print("Rm 1 Temp: ");
  lcd.print(tempAC1);  
  
  delay(800); 
  tempC1 = 0;
  
   if (tempAC1 >= SetPoint1)
      {
        digitalWrite(Damper1, HIGH);
      } 
      else if (tempAC1 <= SetPoint1-2)
      {
        digitalWrite(Damper1, LOW);
      } 
      else
      {
        digitalWrite(Damper1, HIGH);        
      }
  }    
        {
        
        Serial.println(""); 
        Serial.println("Room 2 Raw data: "); 
                                   
        for(i2 = 0;i2<=9;i2++)
        {  
        samples2[i2] = ( voltage * analogRead(tempPin2) * 100.0) / 1024.0;
                                                                             
        Serial.println(samples2[i2]);                                 
                                               
        tempC2 = tempC2 + samples2[i2];
        delay(800);
        
        }
        
        tempAC2 = tempC2/10.0;  

        Serial.print(" Room 2 average " );
        Serial.println(tempAC2);
        
        lcd.setCursor(0, 0);
        lcd.print("Setpoint 2: ");
        lcd.print(SetPoint2);
        lcd.setCursor(0, 1);
        lcd.print("Rm 2 Temp: ");
        lcd.print(tempAC2);    
              
        delay(800);
        tempC2 = 0;
        
           if (tempAC2 >= SetPoint2)
        {
          digitalWrite(Damper2, HIGH);
        } 
        else if (tempAC2 <= SetPoint2-2)
        {
          digitalWrite(Damper2, LOW);
        } 
        else
        {
          digitalWrite(Damper2, HIGH);        
        }
         
        }

                    {
                    
                    Serial.println("");
                    Serial.println("Room 3 Raw data: ");
                                               
                    for(i3 = 0;i3<=9;i3++)
                    {                                      
                    samples3[i3] = ( voltage * analogRead(tempPin3) * 100.0) / 1024.0;
                                                                                 
                    Serial.println(samples3[i3]);
                    
                    tempC3 = tempC3 + samples3[i3];                                  
                    delay(800);                                                  
                    
                    }                                                           

                    tempAC3 = tempC3/10.0;                                           
                    
                    Serial.print(" Room 3 average " );                        
                    Serial.println(tempAC3);
                    
                    lcd.setCursor(0, 0);
                    lcd.print("Setpoint 3: ");
                    lcd.print(SetPoint3);
                    lcd.setCursor(0, 1);
                    lcd.print("Rm 3 Temp: ");
                    lcd.print(tempAC3);    
                                      
                    delay(800);
                    tempC3 = 0;
                    
                    if (tempAC3 >= SetPoint3)
                    {
                      digitalWrite(Damper3, HIGH);
                    } 
                    else if (tempAC3 <= SetPoint3-2)
                    {
                      digitalWrite(Damper3, LOW);
                    } 
                    else
                    {
                      digitalWrite(Damper3, HIGH);        
                    }
            }
}

void upSetPoint1(){

 
  upButton1State = digitalRead(upButton1);
  

  if (upButton1State == LOW) {

    digitalWrite(backlight, HIGH);
    SetPoint1++;
    
  } else {

    digitalWrite(backlight, LOW);
  }
    lcd.setCursor(0, 0);
    lcd.print("Setpoint 1: ");
    lcd.print(SetPoint1);
    lcd.setCursor(0, 1);
    lcd.print("Rm 1 Temp: ");
    lcd.print(tempAC1);
}
void downSetPoint1(){

  downButton1State = digitalRead(downButton1);
  
  if (downButton1 == LOW) {

    digitalWrite(backlight, HIGH);
    SetPoint1--;
    
  } else {

    digitalWrite(backlight, LOW);
  }
    lcd.setCursor(0, 0);
    lcd.print("Setpoint 1: ");
    lcd.print(SetPoint1);
    lcd.setCursor(0, 1);
    lcd.print("Rm 1 Temp: ");
    lcd.print(tempAC1);
}

I'm trying to build a heater damper controller with 3 zones.

So why are you using interrupts at all. There is no need. It is not as if you need lightning response to read a button.
Using an I2C command in an interrupt is going to give you problems because it too uses interrupts to function correctly and when you launch a command from an ISR the interrupts are disabled.

  attachInterrupt(digitalPinToInterrupt(upButton1),upSetPoint1,CHANGE);
  attachInterrupt(digitalPinToInterrupt(downButton1),downSetPoint1,CHANGE);

So, when the switch becomes pressed, call the interrupt handler, AND when the switch becomes released, call the interrupt handler. Makes no sense to me.

Of course, using interrupts for switches doesn't either.

  for(i1 = 0;i1<=9;i1++){                                           
  samples1[i1] = ( voltage * analogRead(tempPin1) * 100.0) / 1024.0;
 
  Serial.println(samples1[i1]);                                           
 
  tempC1 = tempC1 + samples1[i1];                                   
  delay(800);
  }

I see NO point in saving the readings in an array.

      }
  }   
        {
       
        Serial.println("");

I see no point in extraneous curly braces OR your piss-poor indenting.

Tools + Auto Format is tool that you REALLY need to learn to use. It has about a 1.2 second learning curve. Get over the hump.

You should NOT be printing to the LCD in the interrupt service routines. You appear to NOT understand that ISRs are supposed to be lightening fast.

void downSetPoint1(){

  downButton1State = digitalRead(downButton1);
 
  if (downButton1 == LOW) {

Read the state of the pin, and then compare the pin number to LOW. Makes no sense to me.