What is needed for FTDI

My old sketch is still running so I am assuming the bootloader is still on there. I tried another mini that I have successfully programmed via ISP and receive the same error. I read that the FTDI might be flashed with the wrong settings so I downloaded Mprog and reflashed the eeprom with the default settings. then I read and parsed to verify everything was successful. I've also tried re installing the drivers several times.