White boxes in first row of 16X2 LCD display

Post clear photos showing the connection between the Mega and the LCD and the solder connections between the I2C backpack and LCD. To post a photo, just drag it into a reply window and drop it. The image in your original post does not show up.

The I2C pins on the Mega are pins 18 and 19 or the SDA and SCL pins by the pin13 and ground pins.

Have you tried the contrast adjustment?

For an I2C LCD display to work, the I2C address and the I2C backpack to LCD pin mapping must be correct. If the library default settings for either or both are not correct the LCD will not work. You can try to figure out the right pin mapping and use an I2C scanner to find the address, but if you install and use the hd44780 library that is done automatically by the library.

To install the hd44780 library. The hd44780 library is the best available for I2C LCDs. The library is available in the Library Manager. Go to Library Manager (in the IDE menus, Sketch, Include Libraries, Manage Libraries) and in the Topics dropdown choose Display and in the Filter your search box enter hd44780. Select and install the hd44780 library by Bill Perry.

The class that you want to use is the hd44780_I2Cexp class. There are examples to show how to use the library. The nice thing about the hd44780 library is that it will autodetect the I2C address and the I2C backpack to LCD pin mapping.

In the examples, there is a diagnostic sketch that will help us to help you if you still have trouble with the display. Run the diagnostic sketch and post the results.