Will not upload Blink program

OS: Linux Mint 18

Type of board: UNO

Doesn't work out of the box.

IDE 1.8.8

Arduino: 1.8.8 (Linux), Board: "Arduino/Genuino Uno"

Sketch uses 930 bytes (2%) of program storage space. Maximum is 32256 bytes.
Global variables use 9 bytes (0%) of dynamic memory, leaving 2039 bytes for local variables. Maximum is 2048 bytes.
/home/david/Downloads/arduino-1.8.8/hardware/tools/avr/bin/avrdude -C/home/david/Downloads/arduino-1.8.8/hardware/tools/avr/etc/avrdude.conf -v -patmega328p -carduino -P/dev/ttyS0 -b115200 -D -Uflash:w:/tmp/arduino_build_59778/Blink.ino.hex:i 

avrdude: Version 6.3-20171130
         Copyright (c) 2000-2005 Brian Dean, http://www.bdmicro.com/
         Copyright (c) 2007-2014 Joerg Wunsch

         System wide configuration file is "/home/david/Downloads/arduino-1.8.8/hardware/tools/avr/etc/avrdude.conf"
         User configuration file is "/home/david/.avrduderc"
         User configuration file does not exist or is not a regular file, skipping

         Using Port                    : /dev/ttyS0
         Using Programmer              : arduino
         Overriding Baud Rate          : 115200
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 1 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 2 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 3 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 4 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 5 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 6 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 7 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 8 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 9 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 10 of 10: not in sync: resp=0x00

avrdude done.  Thank you.

Problem uploading to board.  See http://www.arduino.cc/en/Guide/Troubleshooting#upload for suggestions.

This report would have more information with
"Show verbose output during compilation"
option enabled in File -> Preferences.