Windows 10 COM issue

I haven’t tried disabling the antivirus yet.. I have however tried disabling driver signature enforcement.. that also failed.. I plugged this board into a Mac at work ( very new ), and it did give me an option for port, but there was only one choice, some kind of Bluetooth port... I wasn’t able to make it work on the Mac either, but I didn’t spend more than 30 minutes investigating.

The computer has an upgraded video card as well as a SSD (which it did not come with). I’m also using a gaming keyboard which uses up 2 USB ports. Aside from that, nothing has been upgraded. It’s probably not relevant, but I figure it can’t hurt to mention. Again, thank you guys for taking the time to help me out here.