WS2801 with high current LED

The transistor is just to turn the LEDs on and off.

Is the value of RXFB what's going to set the current that the NPN turns on/off?

No.

With the required current you must drop 0.6 V across that resistor so RXFB = 0.6 / the led current.

what do I need to look for in an NPN to work with this

One with enough gain to satisfy that equation, and sufficent to carry the required amount of current.