On my DUE it was preventing the 16U2 from resetting the SAM3X and causing the "No device found on COMxx" errors.
It also prevented the SAM3X from being reset after successfully loading a sketch.
I suspect that many others have this same problem on the DUE.
@michaeluna... I've been doing schematic drawings for nearly 50 years and "That" is the most unique and difficult to follow schematic drawing I've seen yet.
That having been said and it wasn't intended as a criticism by any means your work, as far as it goes is OK.
Remember always that a schematic is a road map first and in many cases additional material not usually included in the BOM is represented on the schematic.
Individual circuits like the Power Supplies, Controller and I/O circuitry are usually in separate area's... The Uno drawing is an example of one that is close to the ideal.
I used a high end cad package when I last worked (2008) and I do realize that struggling with a 'difficult' free package has it's special challenges, ones you have done well with.
My best piece of advice would be to study how others (professionals) compose their drawings and try to incorporate (copy the style) of the most legible and understandable ones into your style.
A Schematic drawing is an engineering document used for many different purposes and by many different people. All the way from the poor techie that has to use it for troubleshooting to the people who actually order parts and use the schematic as a means of verifying the BOM for accuracy... of parts and sometimes the count as well.
And let's not forget the other engineers that may need to use the drawing as well... Great work for a beginner.