On opening the monitor, it will reset the Arduino Uno. Not sure if it's a feature or a bug.
After opening the monitor, I get the error "Uncaught TypeError: Cannot read property 'apply' of undefined(…)" in console and then "serial port unavailable" message. If sketch actually write something to the serial (i.e. Serial.println("test")), I get all those messages in the serial monitor for a fraction of a second and then panel disables and shows the error message.
Tested on Chrome and Firefox, same results. Also tried with different boards and USB ports.
Have found that the 101 board is particularly prone to a similar issue and its a known bug.
Leonardo's can also have some minor issues in the way they handle the USB / serial comms.
Not seen the "uncaught type error" bug though. so maybe a few details and or post the sketch that causes it.
If you post the sketch PLEASE use the code tags ( </> ).
Exact same result for Chrome and Edge. Now I'm not getting any error message in console but Serial Monitor panel is simply not available showing "Serial port unavailable".