Arduino pin Interruption with pymata4

Hi friends,
Is there a way to implement arduino pin interruption by using pymata4 library (without using the arduino IDE environment)? We are actually using a python script as a part of our main GUI code.
We have an arduino leonardo, and somehow pyfirmata doesn't work on our laboratory desktop (which is a windows one, while it was working on my personal macbook), so on that windows machine- we had to use pymata4 instead.
can anyone give any idea/suggestion please?

thanks!

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