initialization failed, rc=-1

Dear all,

Good day. I am working on arduino uno boards. I could not able to figure out or right cause to give out above error.whenever i try to upload boot loader i get error. In spite of all connection are correct could not able to remove the error.

avrdude: initialization failed, rc=-1
Double check connections and try again, or use -F to override
this check.

Is there any simple technique to solve the issue. I have USBtiny for uploading boot loader. I have also get below error many times.