Mac - Arduino IDE won't upload to Uno

I recently bought a Mac Mini (2010) running Catalina v10.15.7

I freshly installed the Arduino IDE and I wanted to program my Adafruit VL450X. I have connected the SCL and SDA pins to the chip and the Uno. When I want to upload the sketch it gives me the following error:

Arduino: 1.8.13 (Mac OS X), Board: "Arduino Uno"

Sketch uses 1486 bytes (4%) of program storage space. Maximum is 32256 bytes.
Global variables use 200 bytes (9%) of dynamic memory, leaving 1848 bytes for local variables. Maximum is 2048 bytes.
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 1 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 2 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 3 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 4 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 5 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 6 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 7 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 8 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 9 of 10: not in sync: resp=0x00
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 10 of 10: not in sync: resp=0x00
Problem uploading to board. See http://www.arduino.cc/en/Guide/Troubleshooting#upload for suggestions.

I have tried using a different port, I used 1 and now 4. I have selected /dev/cu.usbserial-640 so that should be fine. I have also tried using three different cables and two different Arduino Uno's. One is 100% new, the other I have been using for a while and I know for sure it works. I haven't tried uploading the sketch on my Windows PC, I could try that, but I kind of want to program my Arduino Uno on my Mac.

Any advice or tips?

is that an original UNO or a clone?
worth trying also the boot loader on that UNO if it's a clone
(I'm running Catalina 10.15.7 on various Macs and have no upload issues)

both of them are clones

They might use a CH340 chip. you might need a driver

I had bought long time ago (now 12€) the driver from https://mac-usb-serial.com, they are signed and work OK (Signed and notarized KEXTs)

There are free download alternatives but I'm always a bit careful on trusting the origin of stuff I install on my Mac

I'll have a look at that! Hopefully it works

they have a free tool (Serial Detect) that lets you see if it detects the extra hardware. try that first

I have installed https://firxworx.com/blog/maker/arduino/installing-ch340-ch34x-drivers-on-macos-for-cheap-arduino-clones/ this CH34X driver. It finally works, thank you very much for the suggestion of installing drivers!

cool - have fun

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